Our group is dedicated to better understand the genetic basis of human immune response variation and translate those insights into the clinic to improve every day medical decision-making. Located both at Helmholtz Munich and the LMU University hospital we are embedded and collaborate in a wide scientific network. The human immune system plays an important role in host protection, autoimmune and inflammatory diseases, cancer, metabolism, and ageing. Given this central role in many human pathologies, it is crucial to understand the variability of immune responses at the population level and how this variability relates to disease susceptibility. However, for the vast majority of these genetic variants, we have little understanding of their functional effects and their context-specificity. Studying the genetic influence on immune response is further complicated by the complexity of the immune system, which consists of many different cell types that respond to a plethora of signals, interact with each other and induce different effector functions under diverse kinetics. Our group integrates state-of-the-art genomic and functional genetic approaches to characterize the genetic basis of human immune response variation to advance our understanding of disease-associated variants and answer questions of genome function plasticity that is shaped by gene-by-environment interactions. We focus in particular on molecular quantitative traits molQTLs in the context of immune activation and disentangle the cell type and context specificity of functional genetic variants with the ultimate goal to develop a roadmap for complex traits at large and enable the move from genetic discovery to functional interpretation and ultimately clinical impact. The composition and maturity of immune cells exhibits high interindividual variability in preterm and term human newborns. Quantitative and qualitative changes of neonatal neutrophils are thought to contribute to the increased susceptibility to bacterial infections and neonatal sepsis that are still a leading causes of mortality and long-lasting morbidity. This interindividual variability is shaped by genetically hard-wired programs, the rapidly changing environment, and the interaction between those two GxE interaction. While elaborate perinatal models in mice and other model systems enable comprehensive research on environmental factors that influence perinatal immune cell development, the genetic basis of human perinatal immune cell variability is still poorly understood and largely understudied. In this project we investigate the role of cis -regulatory variants on protein expression during perinatal immune cell development in human neonates. To do this, we use the Munich Preterm and Term clinical MUNICH-PreTCl birth cohort. Integrating proteome profiles and genotype information of each participant, we will identify genetic variants that determine the variability in protein abundance in neonatal blood samples at defined gestational time points. These so-called protein quantitative trait loci pQTL offer insight into how genetics shape individual phenotypes by understanding the subsequent modulation of distinct protein expression profiles. COVID is an infectious disease caused by the new strain of coronavirus SARS-CoV It was first identified in in Wuhan, China, and has since spread globally, resulting in the —20 coronavirus pandemic. Common symptoms include fever and cough, however disease symptoms as well as disease course and outcome are highly variable ranging from asymptomatic cases to severe pneumonia and death. While Ficken In Michael Haslbeck Str.münchen are likely to have milder symptoms than adults, children of all ages are susceptible to COVID and can suffer from severe disease. Until now it is unknown why children show a different course of disease compared to adults. Studying the immune response to SARS-CoV-2 in children is therefore critical to rapidly advance our understanding of the pathophysiology of COVID both in children and adults. Children offer a unique possibility to study host-related factors that determine COVID severity in the absence of ageing and comorbidity-related interactions, which are largely determining the disease course in adults. We have therefore initiated a functional genetics and genomics COVID study to examine the genetic and environmental risk factors of COVID in pediatric and adult patients. Our group integrates deep immune profiling with multi-omics across multiple molecular levels genome, transcriptome, proteome, metabolome to enhance our understanding of the human immune response to SARS-CoV Following questions will be addressed:. As part of the Child Health Alliance Munich CHANCE initiative this prospective study is performed at Ficken In Michael Haslbeck Str.münchen Dr. The study is also actively involved in national Deutsche COVID OMICS Initiative and international COVID Host Genetics Initiative COVID initiatives to join forces in combating this pandemic. Kasela, S. Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects. Flynn, E. Transcription factor regulation of eQTL activity across individuals and tissues? Brandt, M. An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation? Warnat-Herresthal, S.
Kim-Hellmuth Group
Prof. Dr. Anna Noweck - KSH - Katholische Stiftungshochschule Genetischer Einfluss auf die menschliche Immunantwort · Genetik des Immunsystems in verschiedenen Populationen · Humane perinatale Immunzellentwicklung. Faas, Josef (geboren am in München, wohnhaft. Archivalien gefunden. Kompaktansicht Standardansicht. Kim-Hellmuth Lab | CCRC-HaunerDEFuchs, Georg geboren am Nat Commun 8, Fichtner, Karl geboren am Falck, Erwin Harry geboren am Neues Labormitglied: Modul 6 Student Jöran Sarazzin.
Vita & Funktionen
1. Genetischer Einfluss auf die menschliche Immunantwort · Genetik des Immunsystems in verschiedenen Populationen · Humane perinatale Immunzellentwicklung. Archivalien gefunden. Attenberger Herma, M., Leonrodstr. 26a. Page 3. Hotelliste - Stand 31 Michael-Haslbeck-Str. A B. Atallah Sadik M., Pettenkoferstr. 25/1. Parkhotel Erding. Faas, Josef (geboren am in München, wohnhaft. Kompaktansicht Standardansicht. Lyonel-Feiniger Straße Leopoldstraße. Anmerkung: ae oder ä nach a; oe oder ö nach o; ue oder it nach u. Hotel München-Airport.Open positions: We are actively looking to expand our group at all levels postdocs, senior and junior staff scientists, graduate students, interns. Greubel, Paul geboren am Science Cell Gätzner, Elisabeth geboren am Nat Commun 8, Grams, Hans geboren am Forster, Rosa geboren am Girstenbrey, Franz geboren am Kongress für Infektionskrankheiten und Tropenmedizin Link zum Abstract. Schmid Lab. Franke, Irmgard geboren am Located both at Helmholtz Munich and the LMU University hospital we are embedded and collaborate in a wide scientific network. Gräf, Alois geboren am Fischer, Adolf geboren am 1. Raum: 5. Fleischmann, Konrad geboren am 1. Frey, Hermann geboren am Gierz, Max geboren am 1. PhD student Sathya Darmalinggam joins the lab. Haslbeck med. Göbel, Edeltraud geboren am Gerstecker, Johann geboren am Fiedler, Johannes Dr. Podiumsdiskussion beim LMU Expertinnen-Netzwerk F. Transcription factor regulation of eQTL activity across individuals and tissues? Freese, Gerhard geboren am 3. Gössmann, Alfred geboren am Fischer, Albert geboren am 6. Johannis, wohnhaft in Würzburg, Friedrichstr. Glossner, Josef geboren am 1. Flynn, E. Freudensprung, Adolf geboren am 5.
